Incidence of Invasive Aspergillosis Among Solid Organ Transplant Recipients at the Cleveland Clinic in the 1990's

AFAF MINARI, ROLA HUSNI, ROBIN K AVERY, LONGWORTH L DAVID, BERTIN L MARY, and STEVEN M GORDON

Abstract: 

Invasive aspergillosis (IA) remains a major cause of morbidity and mortality following solid organ transplantation. To describe the epidemiology of IA we performed a retrospective chart review of all solid organ transplant recipients at the Cleveland Clinic with IA from January, 1990 through December, 1999. Definite IA was defined as a positive culture and pathology showing septate hyphae, and probable IA was either a positive culture or histopathology and clinical disease. Disseminated IA was defined as involvement of an extra pulmonary site or two non-contiguous anatomic sites. We identified 30 cases of IA in 2,046 patients (1.5%) for an incidence of 4.4 cases per 1000 patient-years (30 cases/6813 ptyears). The median interval from transplantation to onset of IA was 111 days (range: 37-1563). 77% had definitive IA and 37% had disseminated disease with an overall mortality rate of 70%. The attack rate and incidence rate was significantly higher for lung transplant recipients vs all other solid organ recipients: lung 11% (20 cases/183 patients) or 35 cases/1000-pt-yrs vs heart 0.7% (5/691) or 2.3 per 1000-pt-yrs vs liver 0.5% (2/439) or 1.4 per 1000-pt-yrs vs renal 0.4% (93/ 733) or 1.2 per 1000-pt-yrs (P
2000

abstract No: 

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Full conference title: 

IDSA 38th
    • IDSA 38th