HLA-DQ3 and Alternaria-sensitive Moderate-severe Asthma In Children

A.P. Knutsen, B. Kariuki, H. Vijay, M.R. Shah

Author address: 

St. Louis University Health Sciences, Saint Louis, MO,Health Canada, Ottawa, ON, Canada.


RATIONALE: Sensitivity to Alternaria has been associated with severe asthma. We hypothesized that there may be genetic risks including HLA-DR/DP/DQ associations that may account for this. METHODS: HLA-DR, -DP and -DQ typing was performed on 31 Alternaria-sensitive moderate-severe asthmatic children compared to 37 Alternaria-sensitive mild asthmatic children. Cytokine synthesis was performed on PBMNCs stimulated with Alternaria alternata, Aspergillus fumigatus and Der p extracts. RESULTS: There were no differences of frequencies of HLA-DR and HLA-DP in Alternaria-sensitive moderate-severe asthmatics compared to mild asthmatics. HLA-DQ3 was significantly decreased in moderate-severe asthmatics compared to mild asthmatics, 36% vs 68% (p

abstract No: 


Full conference title: 

American Academy of Allergy Asthma & Immunology
    • AAAAI 2009 (65th)