Genital candidiasis in HIV-infected women in St.-Petersburg, Russia

Buketova1, A.B., Shurpitskaya2, O.A., Vybornova2, I.V., Grigoryeva2, L.G., Shestakova2, T.I., Abakumova2, N.M., Mirzabalayeva2, A.K., Klimko2, N.N.

Author address: 

1 Research Institute of Medical Mycology, SAINT-PETERSBURG, Russian Federation 2 *, SAINT-PETERSBURG, Russian Federation

Abstract: 

The aim of study: is to determine rate and etiology of genital candidiasis (GC) in HIV- infected women and sensitivity of Candida spp. to fluconazole and voriconazole. Methods. 115 HIV-infected women were studied. 113 were in 3d-4th stage of HIV infection, 2 ' in the AIDS. The patient’s age varied 16-48 years (median is 28±1,2 years). The duration of HIV infection varied from 1,5 to 12 years (as average ' 3,7±3,3 years, median ' 2,5 years). All patients had background gynaecological pathology (inflammatory diseases of vagina and cervix of the uterus ' 62,6%, menstrual cycle malfunction ' 36%). Genital candidiasis was diagnosed on clinical manifestation and determined Candida spp. during microscopy and cultural analysis of material from vagina, vulva, cervical canal and urethra. The species determination has been provided using test system Auxocolor-2. The sensitivity of isolates Candida spp. to fluconazole, voriconazole) in vitro due to CLSI M44-A standard. Results: Genital candidiasis has been confirmed in 43% of patients. Candidiasis as monoinfection has been recognized at 22,5% of patients, and candida-bacterial infection has been identified in the rest. The agents of GC as were C. albicans at 57%, 1057;. glabrata at 27%, C. albicans and 1057;. glabrata at 8%, C. parapsilosis at 4%, C. dubliniensis at 2%, C. kefir at 2%. Dose-dependent sensitivity to fluconazole was founded in 53% of Candida glabrata cultures. All other genital candidiasis agents were sensitive to fluconazole. 14% isolates of Candida spp. was sensitive to voriconazole. Resume: Rate of genital candidiasis in HIV-infected women is 43%. The main pathogens of GC at HIV-infected women are C. albicans (57%), which are sensitive to fluconazole, and 1057;. glabrata (27%), 53% of them are dose-dependent sensitive to fluconazole.
2007

abstract No: 

P181

Full conference title: 

3rd Trends in Medical Mycology
    • TIMM 3rd (2011)