GALACTOMANNAN DETECTION IN SERUM AND BRONCHOALVEOLAR LAVAGE FLUID COMPARED TO CT IN PATIENTS AT RISK FOR INVASIVE ASPERGILLOSIS

M.J. Becker, I.A.J.M. Bakker-Woudenberg, C. Schee, H.A. Verbrugh, S. De Marie

Abstract: 

Purpose of investigation: The value of galactomannan detection in serum and bronchoalveolar lavage (BAL)- fluid for the diagnosis of invasive aspergillosis (IA) and its relation with computed tomography (CT) was investigated.Methods: In neutropenic patients serum was sampled 2-3 times weekly. BAL and CT of the thorax were performed at clinical indication. Galactomannan in serum and BAL-fluid was detected by sandwich ELISA (Platelia). Results: Over a 15 month period, 156 patients were included. 18 patients (11.4%) were diagnosed as having a proven or probable IA. The sensitivity of galactomannan detection in serum for diagnosing IA was 61-39%, and the specificity was 70-90%, depending on the criteria that were used to assess the test as being positive. The sensitivity and specificity of the test in BAL-fluid were 75-100% and 100%. The median time difference between positive galactomannan detection and halo- or crescent - or cavity sign on CT was 0 days (range -36 to + 19 days).Conclusion: In BAL-fluid, galactomannan detection showed a high sensitivity and specificity for diagnosing IA, in serum these characteristics were lower. On average, positive galactomannan detection did not precede clinical suspicion for IA.
2001

abstract No: 

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Full conference title: 

22nd International Congress of Chernotherapy (ICC)
    • ICC 22nd