Galactofuranose biosynthesis in Aspergillus niger provides new opportunities for industrial applications in the field of red and white biotechnology

Joohae Park , Boris Tefsen , Ellen Lagendijk , Doreen Schachtschabel , Irma van Die , Arthur Ram

Author address: 

1) Leiden University, Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Sylviusweg 72, 2333 BE Leiden,The Netherlands 2) Department of Molecular Cell Biology and Immunology, VU University Medical Center, van den Boechorststra


Galactofuranose-containing glycoconjugates are present in numerous microbes, many of which are pathogenic for humans. Metabolic aspects of the monosaccharide biosynthesis have proven difficult to elucidate, because galactofuranose metabolites and glycoconjugates are relatively unstable during analyses. Recent advances with genetic approaches have facilitated a better understanding of galactofuranose metabolism. Galactofuranose (Galf) the five-ring isomer of galactopyranose (Galp), is an essential component of the cell wall and required for a structural integrity [1-2]. Recently it has been postulated that Galp bound to UDP, is converted to Galf by a UDP- galactopyranose mutase (UGMA) and subsequently transported into the Golgi by a Galf-transporter named GlfB [3] for the further biosynthesis of e.g. galactomannan, galactoaminogalactan and cell wall glycoproteins (galactomannoproteins) [4-6].

abstract No: 


Full conference title: 

Asperfest 9
    • Asperfest 9 (2012)