Galactofuranose-containing glycoconjugates are present in numerous microbes, many of which are pathogenic for humans. Metabolic aspects of the monosaccharide biosynthesis have proven difficult to elucidate, because galactofuranose metabolites and glycoconjugates are relatively unstable during analyses. Recent advances with genetic approaches have facilitated a better understanding of galactofuranose metabolism. Galactofuranose (Galf) the five-ring isomer of galactopyranose (Galp), is an essential component of the cell wall and required for a structural integrity [1-2]. Recently it has been postulated that Galp bound to UDP, is converted to Galf by a UDP- galactopyranose mutase (UGMA) and subsequently transported into the Golgi by a Galf-transporter named GlfB  for the further biosynthesis of e.g. galactomannan, galactoaminogalactan and cell wall glycoproteins (galactomannoproteins) [4-6].
Full conference title:
- Asperfest 9 (2012)