RATIONALE: The cause of bronchial asthma (BA) is not known, yet. The aim of this study was to establish if the fungi play the role in BA. METHODS: The examination group was composed of 58 patients (34 women, 25 men) with BA in age 4 - 76, average 36.4 y. and control group -12 healthy persons in age 18 -55 (12 women).The diagnosis of BA was performed along the ATS criteria. From patients sputum inhalation test was taken. In the sputum DNA-fungi by PCR method was examinated. We examinated only four fungi: Candida albicans, Aspergillus fumigatus, Fusarium moniliforme, Penicillium notatum.In all patients skin prick test (SPT), spirometry, cultures, history and examination was performed. RESULTS: In sputum from patients with BA in 53/58(91.4%) positive PCR test with fungi was found. Among them: 34/58(58.6%) was Aspergillus fumigatus, 17/58(29.3%) - Candida albicans, 5/58 (8.6%) - Fusarium moniliforme, 2/58(3.4%) - Penicillium notatum. In 5 patiens few fungi in sputum were detected. In healthy patients no fungi DNA was found. In examination group with BA 20/58(34.4%) had positive SPT, among them 3 had food allergy, 7/58(12.1%)- aspirin intolerance, 38/58(65.5%) chronic sinusitis and/or chronic gastrointestinal disorders or recurrent vaginal fungal infections, 36/58 (62.1%) had positive mycological cultures from nose, throat or stool- the most often Candida albicans. CONCLUSIONS: The fungi, especially Aspergillus fumigatus and Candida albicans, play important role in ethiopathogenesis of BA.
Full conference title:
2006 American Academy of Allergy, Asthma, and Immunology Annual Meeting
- AAAAI 2006 (62nd)