Introduction: Fungal infections in liver transplant recipients constitute constantly increase therapeutic problems. Candida genus is the leading fungal pathogen in transplant medicine combine with high risk of morbidity and mortality in liver transplant patients. Aim of study: The aim of our study was to analyze of fungal strains isolated from samples taken from clinical materials of liver transplant recipients hospitalized in Department of General and Liver Surgery Central Clinical Hospital in Warsaw in 2007. Material and methods: The total number of 50 positive clinical samples from liver recipients were examinated, which constituted 39% of positive materials from the Transplant Department: clinical samples were taken from respiratory tract - 30 (59%), wound swabs 6 (12%), urine samples 5 (10%), drain tips 5 (10%), other materials 5 (10%). The specimens were inoculated into Sabouraud's medium with chloramphenicol and gentamicin (bioMerieux). The isolation and identification of the isolates was performed with the use of CHROMAgar (Becton Dickinson) and biochemical test API ID32C (bioMerieux). Results: The collection of fungal isolates included 62 strains, yeastlike fungi 58 strains (94%) and moulds 4 strains (6%). The most often isolated strains from Candida genus were: C. albicans 31 (50%), C. glabrata 9 (15%), C. inconspicua 8 (13%), C. parapsilosis 5 (8%). Other yeastlike fungi constituted 8% - 5 strains. In total 4 strains of Aspergillus fumigatus (6%) were identified. Clinical samples taken from respiratory tracts were positive in 60%, 37 fungal strais were isolated from this material (C. albicans n=19 (51%)). Conclusions: 1.The most common fungal pathogens isolated from liver transplant recipients was C. albicans 31 strains (50%). 2.17 isolates (28%) were natural resistance to fluconazole- primary regimens for yeast infections. 3.Aspergillus fumigatus isolates were cultured in 6% of the total number of fungal strains..
Full conference title:
19th European Congress of Clinical Microbiology and Infectious Diseases
- ECCMID 19th (2009)