Fungaemia in patients with solid tumors

Krcmery V, Babelova O

Author address: 

St. Elizabeth Cancer Institute, Bratislava, Slovak Republic

Abstract: 

Cancer patients, mainly those with haematologic malignancies (acute leukemia), and undergoing bone marrow transplantation(BMT) are at major risk for developing fungaemia. We have studied etiology, risk factors and outcome in cancer patients without hematologic malignances, in individuals with solid tumors (ST). During last 10 years (1988-1997), in our major National cancer institution (National St. Elisabeth cancer institute) fungaemia appeared in 62 patients with solid tumors without BMT or stream cell transplantation. In 35 (56,5), patients fungaemia was caused by C. Albicans, in 24 (38, 7%) by to nonalbicans Candida spp. (C. krusei, C. tropicalis, C. parapsilosis, C. stellatoidea, C. glabrata), and only in 3 due to non-Candida spp. yeasts (4,8%). Attributable mortality (death due to fungaemia) was 18% and crude mortality (death with fungaemia) 11,5%. Major risk factor for development of fungaemia in patients with ST were(i) prior therapy with antiobiotics (85,2%) and (ii) vascular catheter insertion (91,8%) by comparing risk factors, etiology and outcome in fungaemia appearing within the same period in patients with acute leukemia (22 patents, AL group) or lymphoma (17 patients, LY group), we found several risk factors significantly associated with fungaemia in patients with ST: (i) mucositis (59,1% in AL, p
2005

abstract No: 

16

Full conference title: 

15th Annual Focus on Fungal Infections
    • FFI 15th (2005)