A forkhead protein FkhB affects conidiophore development in Aspergillus nidulans and Aspergillus fumigatus.

Dong-Soon Oh, Jong-Hwa Kim and Kap-Hoon Han.

Author address: 

Department of Pharmaceutical Engineering, Woosuk University, Wanju, 565-701, South Korea.


Developmental process in a model filamentous fungus Aspergillus nidulans is controlled by the multiple regulatory systems including signal transduction pathways and transcription factors. We identified a forkhead type transcription factor which is conserved in Aspergillus nidulans, Aspergillus fumigatus and other relatives by using genome screening. The FkhB contains both of conserved forkhead domain (FH) and forkhead associated domain (FHA). To know the function of the FkhB proteins from both species, we deleted the fkhB genes in A. nidulans and A. fumigatus. The fkhB deletion in A. nidulans resulted in abnormal conidiophore formation under standard conditions. In A. fumigatus, fkhB knock-out mutant also produced severely reduced amount of conidiophores, suggesting that the fkhB gene plays an important role in sporulation both in A. nidulans and A. fumigatus. Furthermore, the phenotype is highly dependent in veA gene in A. nidulans. Taken together, the fkhB gene is a regulator of conidiation epistatic with the veA gene. [This work was supported by the NRF grant 313-2008-2-C00804.]

abstract No: 


Full conference title: 

26th Fungal Genetics Conference
    • Fungal Genetics Conference 26th (2005)