FDG-PET Has a Significant Impact on the Diagnosis and Management of Infection in Patients with Hematological Cancer: A Study of 73 Infections in 67 Patients. Session Type: Poster Session 838-III

Tahsine H. Mahfouz, Fariba Saghafifar, Marisa H. Miceli, Laurie B. Jones, Ronald Walker, Raymond Thertulien, Bart Barlogie, Elias J. Anaissie Myeloma

Author address: 

Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA


PURPOSE: To evaluate the value of positron emission tomography (PET) with fluorine 18 fluorodeoxyglucose (FDG) in the detection of infections in patients (pts) with hematologic cancer (hem.ca). MATERIALS AND METHODS: 67 hem. ca. pts (median age 57 years, 63 % males, myeloma 95%) underwent FDG-PET scans because of suspected infection or for disease staging. FDG-PET results were correlated with clinical and laboratory findings. RESULTS: 73 infections were documented in 67 pts. Infections included: pneumonia (33), bone/joint infection (11) [vertebral body osteomyelitis/discitis (6), osteomyelitis/septic arthritis (5 including 1 mastoiditis)], central venous-catheter (CVC)-related septic thrombophlebitis (STP) (9), CVC site infection (7) [pocket of venous ports (5), tunnel and insertion site (1 each)], abdominal infections (5) [colitis (3), abscesses (2)], periodontal abscess (4), and cellulitis (4). Microbiological documentation was obtained in 44 cases: gram positive cocci (26), gram negative bacilli (9), moulds including aspergillus (7), gram positive bacilli (6) including 2 actinomyces, viruses (2), P. carinii and mycobacteria (1 each). FDG-PET detected infectious foci even in the setting of severe immunosuppression [neutropenia, lymphopenia or CD4 cell count (all

abstract No: 


Full conference title: 

American Society of Hematology 45th Annual Meeting
    • ASH 45th (2003)