False Positive aspergillus Antigenemia Related To Concomitant Administration Of Tazocillin.

A. SULAHIAN , S. TOURATIER, T. LEBLANC , P. ROUSSELOT, F. DEROUIN , P. RIBAUD

Author address: 

Lab Parasitology, Hosp Saint-Louis, Paris, France, Pharmacy, Paris, France, Dept Hematology, Paris, France.

Abstract: 

Background: The detection of aspergillus galactomannan antigenemia (GM-Ag) is contributive in the diagnosis of invasive aspergillosis (IA). Transient false positive reactions have been reported using ELISA tests. We report a recent marked increase in the frequency of false positive tests and its relationship with the concomitant administration of tazocillin (TAZO). Methods: Between May 1 and July l5, 931 sera were examined for the presence of GM, using the Platelia ® aspergillus kit (BioRad). The charts of patients (pts) with positive GM-Ag (OD index>1.5) and of 37 pts with persistently negative GM-Ag were reviewed for diagnosis of IA. Concomitant administration of drugs including antibiotics were recorded. Results: In the study period, 103/931 sera were positive (37 pts). The diagnosis of IA was probable in 3 pts and possible in one. For the remaining 33 pts, there was no clinical/radiological sign of IA. In most cases, GM-Ag abruptly increased to high positive value on consecutive samples This was confirmed with different batches of Platelia® kits. Chart review showed that 25/37 pts with positive GM-Ag were receiving TAZO vs 2/37 pts with negative GM-Ag (chi-square= 28.22, p
2003

abstract No: 

M-2062a

Full conference title: 

43rd Interscience Conference on Antimicrobial Agents
    • ICAAC 43rd