Extrinsic Allergic Alveolitis Due to Esparto Fibers Is Caused by Aspergillus fumigatus

Miguel Hinojosa*, Teresa Alfaya*. Pilar Naviof. Santiago Quirce, MD, PhD#, Javier Gauddf, Anronio Sueiro Bendirof

Author address: 

*Allergy Department Ramon y Cajal Hospital Madrid. Spain tPneumology Department% Allergy Department Fundaci6n Jimenez Diaz, Madrid, Spain

Abstract: 

offending agent has not been identified yet. We report two non smoker stucco maker patients, aged 50 and 48, who suffered from recurrent episods of fever, cough, dyspnea and malaise related to the manipulation of esparto in their jobs. Bilateral infiltrates were appreciated on chest radiograph. Aspergillus fumigatus grew in two different samples of esparto. in the two patients. Precipitins to both esparto extract (EE) and Aspergillus fumigatus extract (AFE) were found in the patients sera. Pulmonary provocation tests were performed to each patient with EE and AFE, with a positive clinical response (dyspnea, cough, fever, malaise), physiologic response (decrease > 20% FVC and FEV,) and immunological response (leukocytosis) after 6 hours of the allergenic extract inhalation. Bronchoalveolar lavage after challenge showed marked lymphocitosis and CD4KD8 ratio lower than I. The results of specific IgG determinations and ELISA inhibition assays reflected cross reactivity between EE and AFE. Aspergillus fumigatus was identified as the etiologic agent causing hypersensitivity pneumonitis due to esparto grass fibers.
2000

abstract No: 

S49

Full conference title: 

2000 American Academy of Allergy, Asthma, and Immunology Annual Meeting
    • AAAAI 2000 (56th)