EXPERIENCE OF COMBINATION TREATMENT OF ONYCHOMYCOSIS WITH ORAL ITRACONAZOLE AND TOPICAL AMOROLFINE NAIL LACQUER

Yoon YH, Kim BJ, Ro BI

Author address: 

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Abstract: 

We treated 118 toe nail onychomycosis patients (M/F=72/46) from January 2001 to December 2002. But, among 118 patients we analyzed only 52(44.1%) patients (M/F=33/19) treated by combination therapy composed of twice-weekly application of topical amorolfine 5% nail lacquer and oral itraconazole 3 pulse therapy (the regimen is 200 mg twice daily for 1 week on, 3 weeks off, repeated for 3 consecutive pulses). 15(12.7%) patients treated by 2 pulse and 51(43.2%) patients treated by 1 pulse were excluded. The ratio of distal subungal onychomycosis(DSO) to white superficial onychomycosis(WSO) to total dystrophic onychomycosis (TDO) patients was 47(90.4%) : 3(5.8%) : 2(3.8%). Mean age was 55.3 years old. Diabetics of coexisting disease were more prone to association of onychomycosis. Onychomycosis was diagnosed by positive KOH examination and culture in clinical suspicion. Isolated organisms causing onychomycosis were 48(92.3%) dermatophytes and 4(7.7%) Candida spp. The clinical cure rate of affected nail area was based on decrease of affected nail area by digital camera recording and achieved in 85% ±11.42%(2SD). Oral itraconazole and topical amorolfine nail lacquer combination therapy will be a promising treatment modality for onychomycosis.
2003

abstract No: 

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Full conference title: 

The 15 th Congress of the International Society for Human and Animal Mycology
    • ISHAM 15th (2003)