Expanded Comparative Genomics at the Aspergillus and Candida Genome Databases.

Jonathan Binkley1, Martha B. Arnaud1, Gustavo M. Cerqueira2, Marcus C. Chibucos2, Maria C. Costanzo1, Jonathan Crabtree2, Diane O. Inglis1, Marek S. Skrzypek1, Prachi Shah1, Gail Binkley1, Stuart Miyasato1, Jennifer R. Wortman2, and Gavin Sherlock1

Author address: 

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA 2Institute for Genomic Sciences, University of Maryland School of Medicine, Baltimore, MD, USA

Abstract: 

The Aspergillus Genome Database (AspGD: www.aspgd.org) and Candida Genome Database (CGD: www.candidagenome.org) are curated, web-based genomics resources for researchers studying these diverse and clinically relevant groups of fungi. Initially focused on the well-characterized model organisms Aspergillus nidulans and Candida albicans, respectively, we recently redesigned AspGD and CGD to store and present curated genomic information for multiple species and strains. At AspGD, we currently include strains of A. clavatus, A. flavus, A. fumigatus, A. niger, A. oryzae, A. terreus, and Neosartorya fischeri. CGD will soon include strains of C. dubliniensis, C. glabrata, C. guilliermondii, C. lusitaniae, C. parapsilosis, C. tropicalis, Debaryomyces hansenii, and Lodderomyces elongisporus. In addition to providing sequence information, Gene Ontology annotation, and literature curation for these organisms, additional new features for both AspGD and CGD include: redesigned Locus Summary and Protein Information pages, with expanded links to orthologous loci across the different species; new Homologs pages, displaying multiple sequence alignments and phylogenetic trees for orthologous groups of genes; and a redesigned BLAST tool, allowing queries against any combination of database genomes. In the near future we plan to incorporate many additional genomes (including dozens of A. fumigatus clinical isolates) as well as high-throughput gene expression data from several different species. The expansion of AspGD and CGD to include multiple species will not only directly serve a wider base of researchers, but will also expand the power of comparative genomics for the entire fungal biology community.
2011

abstract No: 

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Full conference title: 

26th Fungal Genetics Conference
    • Fungal Genetics Conference 26th (2005)