Evidence for the Involvement of Two Different MHC Class II Regions in Susceptibility of Protection in Allergic Bronchopulmonary Aspergillosis

Bela Chauhan*, Pafricia Hutcheson*, Howard Schwartzf, Raymond Slavin*, Clifford Bellone*

Author address: 

*St. Louis University School of Medicine, St. Louis, MO tuniversity Suburban Health Center, Cleveland, OH Allergic bronchopulmonary aspergillosis

Abstract: 

hypersensitivity lung disease caused by the fungus Aspergillus fumigatus (Af), occurs in asthmatics and cystic fibrosis patients. To explore the immunological and genetic factors that may be involved in the predisposition to ABPA , we have previously demonstrated the involvement ofAf specific Th2 cells in this disease. In a limited number of patients Th2 reactivity to a major Af antigen (Asp f 1) was restricted exclusively by HLA-DR2 or DR5 alleles. To further assess this association we studied frequencies of HLA-DR/DQ molecules in ABPA patients and controls. Importantly in this study we have included a nonABPA control group consisting of Af skin test positive asthmatic or cystic fibrosis patients who carry a high risk of developing ABPA. A significantly higher frequency of HLA-DR2 was observed in ABPA than in nonABPA (49% vs. 16%. x2=9.4. pc ~0.012) or healthy controls (49% vs. 20%, x2=9.7, pc ~0.012). Genotype analysis revealed that susceptibility to develop ABPA is associated with DR2 subtypes DRB I* 1503 and to a lesser extent by DRB I* 150 1. Presence of the DRB1*1503 allele confers a very high relative risk in nonABPA (pc
2000

abstract No: 

S37

Full conference title: 

2000 American Academy of Allergy, Asthma, and Immunology Annual Meeting
    • AAAAI 2000 (56th)