Evaluation of the Efficacy of Liposomal Amphotericin B (L-AmB) or Caspofungin (CAS) in the Treatment of Experimental Candida albicans Catheter Infection (CI) Using the Antifungal-Lock Technique (ALT).

P. LOPEZ, M. MARTIN, J. GAVALDà, X. GOMIS, N. FDEZ-HIDALGO, I. RUIZ, O. LEN, A. PAHISSA;

Author address: 

Hosp. Vall d'Hebron., Barcelona, Spain.

Abstract: 

Background:The ability of C. albicans to growth adhered to artificial surfaces difficult the treatment of infected prosthetic materials, i.e. central venous catheters. Recommendations for the management of CI due to C. albicans include catheter removal. This presents a problem because in a great number of situations these are highly needed catheter. The aim of this study was to evaluate the efficacy of high concentrations of L-AmB or CAS in the treatment of C. albicans CI using the ALT Methods:New Zealand rabbits were surgically implanted with a silicone catheter trough jugular vein. After insertion the catheter was locked with broth culture containing 107 cfu/mL of CA176 strain. 48 h later ALT was started and catheters were maintained sealed with antifungal solution for another 48 h. Treatament groups were: 1. Control pre-ALT (n=7); 2. Control post-ALT (n=9); 3. L-AmB 5000 mg/L (n=17); 4. CAS (n=18). At appropriate time animals were sacrificed and CI was assessed using trans-catheter blood culture, roll-plate, flushing and sonication techniques. Differences in colony counts were analyzed using Chi-square test and the Mann-Whitney test as appropriate; a P
2006

abstract No: 

M-1750

Full conference title: 

46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 46th