The evaluation of antifungal activity of zinc oxide nanoparticles on growth inhibition of standard strain of Candida dubliniensis

S.S. Hosseini1, S. Roudbar Mohammadi2, H.R. Joshaghani3

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Background: In recent years, the incidence of opportunistic fungi has shown a marked increase. Infection caused by common pathogenic fungi is a significant health problem in immunocompromised hosts. In the present study, antifungal properties of ZnO nanowires and Biocide Sodium dodecile sulfate were examined both in vitro. Materials and Methods: We investigated antifungal activity of ZnO nanowires prepared by a wet chemical method against Candida dubliniensis. ZnO nanowires are characterized by means of scanning electron microscopy (SEM) and X-ray diffraction (XRD) with Cu K radiation, wavelength =1.54178 í… . This study evaluated the anti fungal activity of nanowire ZnO and Biocide SDS against Candida dubliniensis by micro broth dilution assay. The SDS and nanowire ZnO was assessed by broth and agar medium were used to culture the mentioned fungi and Minimum Inhibitory Concentration (MIC) was determinate by first solubilizing them with sterile distilled water followed by serial two-fold dilutions in Sabouraud’s broth using Candida dubliniensis DSY1024 each during compression colony count with control. MIC SDS was diluted at concentration between 0.001-0.56 μg/ml. The nanowire ZnO was diluted at concentration from1.013 to 296 μg/ml. Results: The MIC50, MIC90 and MFC of Nanowire ZnO and SDS against Candida dubliniensis 2.027, 8.88, 15μg/ml and 0.002, 0.007, 0.01 μg/ml determinated, respectively. This study demonstrates the antifungal activity of nanowire ZnO and SDS points out the exceptional efficiency of ZnO which could represent candidates in the inhibitory. Conclusion: Based on these results ZnO nanowires could represent a template for elimination of Candida in medicine particular in medical instruments. Key words: Candida albicans, ZnO nanowires, antifungal test.

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Iranian Congress on Medical Mycology
    • ICMM 2011