Estimating the burden of serious fungal diseases in Thailand

Methee Chayakulkeeree, David W. Denning

Abstract: 

Background: Serious fungal infection in Thailand is common but data regarding its incidence and prevalence is lacking. Objectives: To estimate the incidence and prevalence of serious fungal diseases in Thailand based on the size of the populations at risk and available epidemiological databases to indicate the national burden of these conditions. Methods: Data derived from The Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, World Health Organization (WHO) and international and local reports published were used in the present study. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology by LIFE. Results: The population of Thailand is around to 65,000,000; 18% are children, and 14% are women > 60. Recurrent vulvovaginal candidiasis (> 4 episodes/year) is estimated to occur in 3310/100,000. Using a previously described rate that 14/10,000 admissions had fungemia and 94% were Candida, we estimate 8,650 patients with candidemia. Due a relatively high incidence of pulmonary tuberculosis (TB) in Thailand, the prevalence of chronic pulmonary aspergillosis is relatively high - a total of 13,092, approximately half following TB. Invasive aspergillosis is estimated to affect 941 patients following leukaemia therapy, transplantation and COPD, ~1.4/100,000. In addition, ABPA and SAFS were estimated in around to 58.4/100,000 and 77/100,000 respectively, in 1.5 million adult asthmatic patients. Given a 450,000 HIV population, with around to 8,134 new cases of AIDS annually, cryptococcal meningitis, Pneumocystis pneumonia and Talaromyces marneffei infection are estimated at 1.9/100,000, 2.6/100,000 and 0.3/100,000, respectively. Conclusions: The present study indicates that around to 2.15% (1,400,717) of the population is affected by non-cutaneous fungal infections. Due the lack of data, reports and statistics, the number of patients with mycoses in Thailand can only be estimated. Further epidemiological studies are needed to validate and extend these estimates.

2015

abstract No: 

381

Full conference title: 

19th Congress of the International Society for Human and Animal Mycology
    • ISHAM 19th (2015)