Ephicacy of nebulized amphotericin B for prevention of Aspergillus infection in lung transplantation.

A.Roman, V. Monforte, J. Gavalda1 , C. Bravo, A. Ferrer, M. Rochera, R.Angles, J. Sole, E Morell.

Abstract: 

Aim:To evaluate the efficacy and safety of nebulized amphotericin B (nAmB) for prevention of Aspergillus infection in lung transplant patients.Methods:We compared the first nine consecutive lung transplanted patients who did not receive prophylaxis (Group 1) with the next 26 patients who received nAmB (Group 2). Starting at day 1 postop., six rag were nebulized every 8 hours the first four month postoperative and later once a day for life. We used a jet nebulizer (System 22 Acom) and CR60 compressor.Aspergillus infection was diagnosed when more than two respiratory samples were positives for Aspergillus, and at least, one of these were obtained by bronchoscopy. Aspergillus tracheobronchitis (T) was diagnosed by clinical symptoms plus bronchoscopic findings (Bch) with red edematous mucosa and mucus plugging. Ulcerative tracheobronchitis (UT) was diagnosed by bronchial biopsy andlor Bch with necrotic ulcers that disappeared after treatment. Invasive pulmonary aspergillosis (IPA) was diagnosed by lung histopathology.Results:
1997

abstract No: 

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Full conference title: 

7th European Respiratory Society Annual Conference
    • ERS 17th (2007)