Eosinophilic pulmonary syndromes: Retrospective study of the past 18 years in Coimbra University Hospital

Pedro Gonçalo Ferreira, António Jorge Ferreira.

Author address: 

Pneumology, Coimbra University Hospital, Coimbra, Portugal


Background: The eosinophilic pulmonary syndromes (EPS) are defined as an heterogeneous group of diseases characterized by various degrees of blood and/or pulmonary tecidular eosinofilia. Methods: Retrospective study regarding cases diagnosed following admission in Coimbra Univ. Hospital over 1989-2007 Results: 17 cases were considered for study: 7 of Chronic Eosinophilic Pneumonia (CEP), 2 of Drug-induced Pneumonia (DIP); 2 of Allergic Bronchopulmonary Aspergillosis (ABPA); 2 of Acute Eosinophilic Pneumonia (AEP); 2 Idiopatic Loeffler Syndromes (ILS); 1 Churg Strauss Syndrome (SCC) and 1 Idiopatic Hipereosinophilic Syndrome (IHS). The commonest presentation symptoms were persistent dry cough and chest pain. Radiologically, we found mainly alveolar aspects (31%), reticular interstitial patterns (25%), ground glass attenuation (43%), and 12% showed migratory infiltrates. In 35.3% a possible etiology was credited to drugs. 29.4% of the patients had history of an atopy and 35.3% of smoking. 38.5% had an obstructive pattern, 15.4% restrictive, 7.7% a mixed pattern, and 30.8% a decrease in DLCO. About 47% had blood eosinophilia, 60% eosinophilia in the BALF, and 75% had elevation of total IgE levels. Lung biopsies were carried in 64%. Corticoid therapy was instituted in only 41.2% of cases. 23.5% of cases required admission to the ICU. Conclusions: There was an expected subdiagnose.The majority of cases were CEP, although there was a surprisingly few cases of CSS and ABPM. Corticotherapy was underutilized. EPS are often difficult to distinguish amongst themselves due to the overlapping of clinicoradiological and histological features as to the miscellaneous form of disease progression.

abstract No: 


Full conference title: 

20th European Respiratory Society conference
    • ERS 20th (2010)