Emergence of Candida glabrata Resistance to Itraconazole

M. LUCZAK 1,2, E. SWOBODA KOPEC 1,2, B. SULIK TYSZKA l, D. KAWECKI 2, M. WROBLEWSKA 2.

Author address: 

1Central Clinical Hospital in Warsaw, Poland 2Medical ~Tziversi~ of Warsaw, Poland

Abstract: 

Objective: To analyze the susceptibility of C glabrata strains isolated from surgical patients hospitalized in the Central Clinical Hospital (CCH) in Warsaw Significance: Evaluation of iesistmlce of clinical strains of Camiida glabrata to itraconazole Study Design: Antifungal susceptibility testing of clinical isolates Setting: Surgical ward of a university hospital Population: Surgical patients hospitalized in the 1200 bed CCH in 2004 Methodology: Standard mycological cultures were done on tile following clinical samples: peritoneal swabs taken during surgery, peritoneal fluid, blood, bronchial washings, bile, drains, catheters, pus and urine. Isolated yeast like fungi were identified by 1D32C assay (bioMerieux, France). Susceptibility to mltifungal agents was tested by E-tests (AB Biodisk). Results: Out of 1 652 specimens yielding fungal growth, 1 722 fungal strains were isolated. There were 664 fungal isolates cultured from surgical patients. Among them there were 188 strains of C. glabrata. Resistance to itraconazele was detected in 62 strains (33%) of C. glabrata. The majority of itraconazole-resistant isolates were cultured from peritoneum - 25 (40.3%) and blood cultui~es - 13 (21%1). Conclusion: Surgical patients are at risk for infections caused by C glabrata. An emergence of itraeonazole resistant strains of C. glabrata was observed in the analyzed group of patients.
2005

abstract No: 

A1.23

Full conference title: 

International Congress on Chemotherapy, 24th Meeting
    • ICC 24 th