Efficacy of Voriconazole (VCZ) Against Experimental Pulmonary Aspergillosis in Japanese Quail (Coturnix japonica) .

. A. TELL1, K. V. CLEMONS 2,3,4, Y. KLINE 1, L. WOODS 1, D. A. STEVENS 2,3,4;

Author address: 

1Univ. of Calif., Davis, CA, 2Calif. Inst. Med. Res., San Jose, CA, 3Sta. Clara Vly. Med. Ctr., San Jose, CA, 4Stanford Univ., Stanford, CA.

Abstract: 

Background: A. fumigatus commonly causes morbidity and mortality in wild and domestic birds. Currently, itraconazole is the drug of choice for treating avian aspergillosis; VCZ treatment has yet to be investigated. Methods: 10-d old quail were infected intratracheally with 106.5 viable A. fumigatus conidia mimicking the natural infection route. Nine once daily treatments (n = 20/group) with oral (PO) VCZ at 20 or 40 mg/kg were initiated 24 h post-inoculation (PI); control birds were given saline PO. Pre-assigned subgroups of 10 birds were euthanized on d 5 and 10. Lung lobes were divided for histology and culture. Survival data to d 10 was analyzed. Results: At d 10, survival for the 40 and 20 mg/kg and control groups was 95, 70, and 43%, respectively. By log rank test, VCZ at 40 mg/kg increased survival compared to 20 mg/kg and controls (p
2006

abstract No: 

M-1745

Full conference title: 

46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 46th