Purpose: To study the efficacy of anidulafungin in a murine model of disseminated infection by Aspergillus flavus. Methods: Mice were rendered neutropenic by intraperitoneal cyclophosphamide and intravenous 5-fluorouracil administration. Animals were infected intravenously with 1x104 cfu of A. flavus and treated with anidulafungin at 1, 5 and 10 mg/kg/day intraperitoneally. Treatment began 1 day after infection and continued for 7 days post-infection. The efficacy of anidulafungin was evaluated by survival, tissue burden studies in kidney and spleen, and detection of serum galactomannan. The experiments were performed with two different strains. Results: The three doses of anidulafungin tested significantly improved survival and reduced the tissue burden significantly with respect to the control group. All doses were able to reduce the galactomannan in serum. Conclusions: Anidulafungin could play an important role in the treatment of disseminated infections by A. flavus.
Full conference title:
4th Advances Against Aspergillosis
- AAA 4th (2010)