Efficacy of Abelcet in a Rabbit Model of Coccidioidal Meningitis.

J. CAPILLA1,2,3, R. A. SOBEL 3,4, K. V. CLEMONS 1,2,3, D. A. STEVENS 1,2,3;

Author address: 

1California Inst. for Med. Res., San Jose, CA, 2Santa Clara Vly. Med. Ctr., San Jose, CA, 3Stanford Univ., Stanford, CA, 4VA Med. Ctr., Palo Alto, CA.

Abstract: 

Background. Coccidioidal meningitis (CM) is highly lethal, particularly in patients with associated vasculitis, even with appropriate therapy. We evaluated the efficacy of Abelcet (ABLC) in comparison to fluconazole (FZ) and conventional amphotericin B (dAMB) in a previously described rabbit model of CM. Methods: Groups of 8-9 male New Zealand White rabbits (2.5-3 kg) were infected intracisternally with 104.7 viable arthroconidia and clinically assessed daily for 26 d. Beginning 5 d after infection, they received D5W (control), dAMB 1 mg/kg, or ABLC 7.5 or 15 mg/kg by i.v. drip 3 times/wk for 3 wks. FZ was given p.o. once/d for 19 d. Blood was obtained for drug level determination. Brain and spinal cord were processed for histology and CFU. Results: D5W and FZ animals lost weight and had decreased motility. All treatment groups had prolonged survival in comparison to D5W (all p = 0.005). There were 0 and 67% deaths, respectively, at d 26. Treatments reduced CFU in brain and spinal cord vs. D5W (all p
2006

abstract No: 

M-1748

Full conference title: 

46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 46th