The effects of caspofungin and voriconazole in experimental Candida otitis media

Cetinkaya Z., Ayeicek A., Kiyiei H., Cifteu H., Asik G.

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PURPOSE: To evaluate the effectiveness of caspofungin and voriconazole in the treatment of experimental Candida otitis media in an experimental rabbit model. METHODS: Thirty New Zealand white rabbits were divided into four treatment groups and one control group. Rabbits were immunosuppressed by cyclophosphamide and triamcinolone acetonide. Right ear of each rabbit was infected by injection of the inoculum of 0.1 ml (10000/0.1 ml) of C. albicans into the middle ear cavity. Seventy hours after the inoculation, Amphotericin B 1 mg/kg/day (n: 6), itraconazole 10 mg/kg/ day (n: 6), voriconazole 10 mg/kg/day (n: 6) and caspofungin 5 mg/kg/day (n: 6) were injected to the each treatment group. No antifungal drug was administered to the control group (n: 6). Clinical and histopathologic examination scores and microbiological analysis of middle ear mucosa were compared. RESULTS: There was statistically significant difference in the clinical scores, histopathologic scores, and mean CFU/g between the treatment and control groups (p

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17th International Society for Human and Animal Mycology
    • ISHAM 17th (2009)