The Effects Of Aspergillus Colonization On Pulmonary Function In Cystic Fibrosis

G.R. Graff, J. Poehler, G. Francisco, P. Konig.


Aspergillus (ASP) is a frequent endobronchial colonizer of the airway in cystic fibrosis (CF). However, the effects of ASP on pulmonary function are unknown. We performed a retrospective chart review on patients 6 years and older who were colonized with ASP. Colonization was defined as 2 or more cultures that grew ASP within 1 year. FVC, FEV_{1}, and growth parameters were examined. Additionally, we determined how prevalent allergic bronchopulmonary aspergillosis (ABPA) was in this patient population. Eighteen patients were found who met criteria with mean age (range) being 15.0 (6.9-28.5) years. The percent predicted FVC and FEV_{1} (mean ± SE) one year prior to colonization was 64.5 ± 4.4 and 49.4 ± 4.5. At the time of colonization the FVC and FEV_{1} were 64.2 ± 4.9 and 50.9 ± 4.5, while one year after initial colonization they were 64.4 ± 3.6 and 50.1 ± 4.4 (p = NS). Height and weight velocities were not affected by ASP colonization in the pediatric group. One patient developed ABPA. ASP colonization occurs commonly in CF patients with more advanced lung disease, however, ASP colonization does not seem to have an adverse effect on pulmonary function.

abstract No: 


Full conference title: 

The American Lung Association - American Thoracic Association Conference,1998
    • ALA-ATA