Effect of Sensitization and Exposure to Mold On Asthma Morbidity in Inner-City Children

Jean Curtin-Brosnan, Patrick J. Lenehan, Patrick Breysse, Gregory B. Diette, Elizabeth Matsui

Abstract: 

Journal of Allergy and Clinical Immunology, Vol. 131, Issue 2, AB123

Rationale

To examine the relationship between sensitization and exposure to mold and asthma morbidity in inner-city children.

Methods

144 children (5-17 years old, 57% male and 91% black) with persistent asthma were studied for one year. At baseline, subjects underwent skin testing to Alternaria, Aspergillus, and Cladosporium. A net wheal ≥3mm was considered positive. Home assessments were conducted every three months. Mold exposure was defined as any signs of mold: moisture or water damage, musty smells or visible mildew. Symptoms and asthma-related health care use were assessed by questionnaire every three months. Participants were grouped into four categories: not sensitized to either of the two indoor molds and not exposed; sensitized/not exposed; exposed/not sensitized; and sensitized and exposed. Generalized linear mixed-effects models and Wilcoxon rank-sum tests were run to determine associations between group and measures of asthma morbidity.

Results

At baseline, 51% of subjects were SPT+ to one or more of the 3 tested molds (Alternaria 34%, Aspergillus 29%, and Cladosporium 7%).Twenty percent had moisture or water damage, musty smells or visible mildew in bedrooms/family rooms. Sensitization to mold was not associated with any asthma-related symptoms or acute care visits. After controlling for gender, age, and total IgE, sensitization and exposure to mold was associated with emergency department visits (OR, 2.06;CI 1.10-3.87), days of slowed activity (OR, 1.8;CI 0.96-3.56) and exercise-related symptoms (OR, 2.0;CI 0.98-3.95), although the symptoms associations were not statistically significant.

Conclusions

Sensitization to mold was not associated with asthma-related symptoms, but sensitization and exposure to mold was associated with symptoms and ED visits.

http://dx.doi.org/10.1016/j.jaci.2012.12.1111

Journal of Allergy and Clinical Immunology, Vol. 131, Issue 2, AB123

abstract No: 

447
    • AAAAI 2013 (69th)