Donor’s Toll-like Receptor (TLR) 4 Haplotypes Increase the Incidence of Invasive Mold Infections (IMI) in Hematopoietic Stem Cell Transplant (HCT) Recipients.

P. Y. BOCHUD1, J. W. CHIEN 2, M. JANER 1, K. A. MARR 2, A. ADEREM 1, M. BOECKH 2;

Author address: 

1Inst. for Systems Biology, Seattle, WA, 2Fred Hutchinson Cancer Res. Ctr., Seattle, WA.

Abstract: 

Background: The study goal was to assess the risk of post-allogenic HCT IMI and CMVD associated with recipient/donor TLR mutations. Methods: 22 single nucleotide polymorphisms (SNPs) in TLRs 2,3,4 and 9, including 16 minimal haplotype tagging SNPs, were analyzed in 407 HCT recipients/donors. Probability/risk of IMI (36 eligible cases, 25 in donor analysis) and CMVD (n=26) associated with TLR polymorphisms was assessed using cumulative incidence curves and multivariable cox regression models. Results: Presence of donor haplotypes 5 or 7 strongly increased the probability of IMI (log rank test, P<.001 and="" p=".02)," haplotype="" tended="" to="" increase="" the="" probability="" of="" cmvd="" compared="" presence="" donor="" haplotypes="" other="" than="" adjusted="" risk="" imi="" was="" associated="" with="" tlr4="" ci="" bonferroni="" adj.="" there="" a="" trend="" toward="" an="" association="" between="" is="" in="" ld="" snps="" t399i="" which="" impair="" function.="" conclusions:="" strongly="" increased="" hct="" recipients.="" observation="" needs="" further="" confirmation="" because="" its="" considerable="" importance="" for="" possible="" intervention="" strategies.="">
2006

abstract No: 

B-1329

Full conference title: 

46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 46th