Determinants of bronchial hyperresponsiveness (BHR) in patients with allergic rhinitis (AR)9734;

N. Metea, O. Gulbahara, A. Sina, M. Erdincb, F. Sebika, A. Kokuludaga

Author address: 

a Internal Medicine, Division of Clinical Immunology and Allergy, Ege University Medical Faculty, Izmir, Turkey b Chest Diseases, Ege University Medical Faculty, Izmir, Turkey


Rationale Patients with AR and BHR have a higher risk of developing asthma. In this study, we investigated whether reactivity to aeroallergens in skin prick test (SPT) and serum eosinophil cationic protein (sECP) levels could be used to predict BHR in AR. Methods Fifty-nine consecutive patients diagnosed with AR between February 2001 and February 2002 were studied. SPTs were performed using grass, tree, weed, parietaria, Alternaria, Aspergillus, mites and cat and dog dander extracts. Methacholine challenge test was performed using spirometry. Results Methacholine induced BHR was detected in 23 patients (39%). Of the 59 patients, 14 had one positive SPT response, 35 had 2-4 and 10 had >4 positive responses. There was a significant inverse correlation between methacholine PC20 doses and the number of positive SPTs (p=0.031, r=8722;0.28). BHR(+) patients had a mean of 4 positive SPTs while BHR(-) patients had a mean of 2.6 (p=0.04). Of the 23 BHR(+) patients, 39% had >4 positive SPTs. In contrast, only 2.7% of the BHR(-) patients had >4 positive SPTs (p=0.0001). The mean methacholine PC20 dose was 5.05 ± 9.72mg/ml in patients with >4 positive SPTs, 23.4 ± 14mg/ml in patients with 2-4 and 23.6 ± 13.4mg/ml in patients with one positive response (p=0.001 for >4 vs. 24, P=0.002 for >4 vs. 1). There was no correlation between sECP levels and methacholine PC20 doses. Conclusions AR patients with SPT responses to a higher number of allergens are more likely to have BHR. Whether the number of positive SPT responses correlates with the risk of developing asthma in AR remains to be determined.

abstract No: 

Page S198

Full conference title: 

2004 American Academy of Allergy, Asthma, and Immunology Annual Meeting
    • AAAAI 2004 (60th)