Cytokine pro64257; le of patients with invasive aspergillosis: initial results from the 64257; rst 100 patients recruited into the aspergillosis study; Great Britain

M.M. Ceesay, S. Kordasti, L. Berry, J. Wade, M. Smith, G. Mufti, A. Pagliuca

Author address: 

King’s College Hospital (London, UK)

Abstract: 

Objectives: Invasive Aspergillosis (IA) is an important cause of morbidity and mortality in haemato-oncology patients undergoing haematopoietic stem cell transplantation (HSCT) or highdose chemotherapy. We set up an observational prospective cohort study in order to improve our diagnostic and management strategies using the EORTC/MSG criteria as a diagnostic tool. Here we assess the serial cytokine profi le of patients to evaluate their potential role in the diagnosis and management of IA. Methods: All study patients were prospectively recruited and followed up for 149; 4 months after chemotherapy or HSCT and had baseline and fortnightly follow-up serum samples profi led for 30 infl ammatory cytokines using multiplex bead immunoassays by Luminex 100TM instrument. The cytokines measured were: EGF, Eotaxin, FGF, G-CSF, GM-CSF, HGF, IFN-a, IFN-g, IL- 1RA, IL-1b, IL-2, IL-2R, IL-4, IL5, IL6, IL7, IL-8, IL-10, IL-12p40/ p70, IL-13, IL-15, IL-17, IP-10, MCP-1, MIG, MIP-1a, MIP-1b, Rantes, TNF-a and VEGF. The fi rst hundred patients enrolled with suffi cient follow up data were included in this initial analysis. We used generalised logistic regression model for binary outcome of proven/probable and no evidence of IA (R2=0.4355, P
2011

abstract No: 

P1054

Full conference title: 

Annual Meeting of the EBMT, 37th
    • EBMT 37th (2011)