Curation of Aspergillus gene and protein information at the Aspergillus Genome Database (AspGD)

Diane Inglis[1] Martha B. Arnaud[1] Jon Binkley[1] Maria C. Costanzo[1] Marcus C. Chibucos[2] Jonathan Crabtree[2] Joshua Orvis[2] Prachi Shah[1] Marek S. Skrzypek[1] Gail Binkley[1] Stuart R. Miyasato[1] Jennifer Wortman[2] Gavin Sherlock[

Author address: 

1Department of Genetics, Stanford University School of Medicine, Stanford, CA 2Institute for Genomic Sciences, University of Maryland School of Medicine, Baltimore MD


The Aspergillus Genome Database (AspGD; is a web-based genomics resource for researchers studying the genetics and molecular biology of an important group of fungal microorganisms, the aspergilli. AspGD provides high-quality manual curation of the experimental scientific literature, including gene names, general descriptions, phenotype data, and Gene Ontology (GO) annotations, as well as tools for exploring these data. AspGD is based on the framework of the Saccharomyces Genome Database (SGD) and Candida Genome Database (CGD), two genomic resources with which many users within the fungal research community are already familiar. The manual annotation of gene information, phenotype data and GO annotations is the focus of this presentation. Initially, we have focused on the manual curation of genomic information for Aspergillus nidulans, the best-characterized species of the group. We will expand our efforts to include curation of A. fumigatus, A. flavus, A. oryzae, A. niger, A. clavatus, A. terreus, and Neosartorya fischeri genomes. The curation process for gene-specific information entails screening of the published literature to identify the relevant journal articles, and manual evaluation of each paper by trained scientific curators, who extract the information for collection into the database using structured vocabularies (such as GO and our phenotype description system) as well as free-text descriptions. The curated information for each gene appears in brief on its Locus Summary page, which links out to details pages that provide additional information, including phenotype and GO details, a history of sequence and annotation that affect the gene, and a comprehensive list of references. We welcome questions, requests for data, comments, or suggestions to help us better serve the needs of the research community, and encourage researchers to contact us at AspGD is supported by grant RO1 AI077599 from the NIAID at the NIH.

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Full conference title: 

    • ECFG 10th (2010)