Cumulative Discontinuous Neutropenia Predicts Risk of Invasive Aspergillosis both during and after Resolution of Neutropenia in Patients with Hematologic Malignancy

R.C. Watker*, N. Issa, T.L. Hoskin, J.L. St Sauver, C.D. Schteck.

Author address: 

Mayo Clinic Collese of Medicine, Rochester, MN, USA


Problem: Cumutative discontinuous neutropenia (CDN) denotes the totat number of days of neutropenia that can accrue across muttipte episodes of chemotherapy-induced neutropenia - and may predict risk for infection. Determining CDN is difficult because patients do not have blood tests every day. Method: We developed software that extracts existing neutrophil counts and then derives, by interpolation, a neutrophil count for every day in between. We then analyzed all cases of leukemia (861) and lymphoma (1418) at Mayo CUnic from 1990 to 2000. For each case, a date-specific flew was built that indicated whether or not the patient was neutropenic (absolute neutrophil count

abstract No: 


Full conference title: 

14th International Symposium of Infections in the Immunocompromised Host
    • ISIIH, 14th