Contact Dermatitis Due To Topical Amorolfine

Dr. Ruperto Gonzalez Perez, Mrs. Paloma Poza-Guedes, Mrs. Inmaculada Sánchez Machín, Dr. Victor Matheu, MD

Author address: 

Hospital del Tórax-Ofra, Sta Cruz de Tenerife, Spain

Abstract: 

Rationale

Contact eczema caused by allergy to antifungal drugs is uncommon. Imidazole derivatives have been described as the most sensitising agent.

 

Methods

We report the case of a 49 year-old female non-atopic patient presenting with an extensive eczematous pruritic rash on her right great toe. She had been prescribed 3 weeks before a topical cream twice daily containing 0,25% amorolfine, polyethylene glicol 40 monosterate, stearyl alcohol, parafin, carbomer 934P, sodium hydroxyde, disodium edetate, 2-phenoxy ethanol and purified water. Patch test were performed with the suspected antifungal cream.

 

Results

Patch test showed positive (+++) readings at 48 and 96 hours. Five control subjects obtained negative patch test with the same suspected cream. A negative result to a cosmetic battery was also included to exclude the rest of the cream components.

 

Conclusions

we describe the rare case of a contact dermatitis due to amorolfine. To our knowledge only three cases have been previously reported in the literature review.

abstract No: 

685
    • AAAAI 2014 (70th)