Congenitally C5-Deficient Mice Have increased Susceptibility to Invasive Aspergillosis.



In vitro studies show that fresh complement is required for optimal phagocytosis of Aspergillus fumigatus conidia by peripheral blood effector cells, and that the chemoattractant C5a is generated in the presence of either conidia or hyphae. However, there is only limited in vivo evidence supporting a role for complement in host defense against invasive aspergillosis. We therefore contrasted lethality of A.fumigatus infection in congenitally C5-deficient mice vs. outbred immunologically intact CD-1 mice. Conidia (2x10') were injected intravenously, and deaths were recorded. The following organs were examined for hyphal invasion and inflammatory response: lungs, brain, heart, liver, spleen, and kidneys. Compared to immunologically intact CD-1 mice, C5-deficient animals showed markedly decreased numbers of neutrophils in foci of hyphal invasion, presumably due to absence of C5a. These in vivo data suggest that the complement cascade plays a pivotal role in host defense against invasive aspergillosis.

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ICAAC 33rd, 1993
    • ICAAC 33rd