Comparison of in vitro antifungal susceptibilities of conidia and hyphae of Aspergillus spp

Lass-Flörl, C., Speth C., Dierich MP.


The minumum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) ofamphotericin B, lipid based amphotericin B formulations, itraconazole and voriconazole againts 37 isolates of Aspergillus spp. comprising 15 isolates of Aspergillus fumigatus, 12 of Aspergillus flavus and five each of Aspergillus niger and Aspergillus terreus were tested using a broth microdilution method according to the guidlines of the National Committee for Clinical Laboratory Standards (NCCLS M 38-P). In addition, we applied a broth microdilution assay for hyphae of Aspergillus spp. since the invasice form is manifested by the appearance of hyphal structures. MICs and MFCs of hyphae were significantly higher (p

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6th Congress of the European Confederation of Medical Mycology Societies
    • ECMM 6th (2000)