Comparative susceptibilities of C. albicans and non C. albicans isolated from recurrent vulvovaginal candidiasis against clotrimazole and fluconazole

S. Sharifynia1, M. Falahati2, L. Akhlaghy2, S.A. Yazdanparast1, A. Foroumadi3

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Background: Candidal vulvovaginitis is a female genital system infection that occurs by overgrowth of Candida species especially with Candida albicans which may be recurrent. Long administration of current drugs may cause resistance. Therefore it is essential to understand the efficacy pattern of therapeutic agents against isolated candida species from vaginitis. Material and methods: this was an experimental-descriptive study that was performed on 150 suspected patients. All specimens were examined based on direct microscopy and culturing. Furthermore complimentary tests such as culture on candida Chromagar, corn meal agar, germ tube test, susceptibility to cycloheximide, temperature test, sugar assimilation test (with API 20 kit) to differentiate candida species were performed. In addition, the effect of current azole drugs by micro dilution broth method was tested. Results: out of 150 specimens of suspected volvuvaginal candidiasis overall 80 cases were diagnosed as true candidiasis. Most of the isolated agents were Candida albicans, C. glabrata, C. parapsilosis, C. krusei and C. giullermondi. 30.43% of C. albicans and 70% of non C. albicans were resistance to clotrimazole and 8.69% of C. albicans and 50% non C. albicans were resistance to fluconazole. Discussion: for the prevention of recurrent cases and to establish correct diagnosis and choose effective therapy it is essential to carryout Laboratory tests such as API and antifungal susceptibility tests. Key words: Candidal vulvovaginitis, antifungal susceptibility test, candida species

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Full conference title: 

Iranian Congress on Medical Mycology
    • ICMM 2011