Comparative Antifungal Activity of the Echinocandin FK463 against Disseminated Candidiasis and Invasive Pulmonary Aspergillosis in Persistently Neutropenic Rabbits.

V. PETRAITIS, R. PETRAITIENE, A. GROLL, T. SEIN, R.L. SCHAUFELE, J. BACHER, T.J. WALSH

Abstract: 

In vitro studies demonstrate that FK463 (FK) has broad-spectrum activity against Candida and Aspergillus species. Little is known about its comparative antifungal activity in persistently neutropenic hosts. Therapeutic efficacy of FK against experimental disseminated candidiasis (DC) and invasive pulmonary aspergillosis (IPA) was studied in persistently neutropenic rabbits. Candidiasis: Treatment was started 24h after IV inoculation of 1x103 Candida albicans (CA) blastoconidia. Study groups: untreated controls (UC), FK at 0.25(FK0.25), 0.5(FK0.5), 1(FK1), or amphotericin B 1(AmB) mg/kg IV. Rabbits treated with FK0.5, FK1, and AmB showed significant dosage-dependent tissue clearance of CA in liver, spleen, kidney, and brain (p
2000

abstract No: 

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Full conference title: 

Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 40th