Imbalances in the pool of amino acids in fungi result in a coordinated derepression of amino acid biosynthetic genes (general control) and has been described in Neurospora crassa, Asperaillus nidulans, and Saccharomyces cerevisiae. Recently, a gene (cpc-2) from Neurospora crassa has been cloned (MGG, 248, 162-173) which influences general control as well as formation of female sexual organs (protoperithecia). Here, we report the cloning of cpcB, the Neurospora crassa cpc-2 homologue from Aspergillus nidulans. cpcB encodes a protein entirely composed of WD-repeats and is highly homologous to similar proteins from eukaryotes including fungi, plants, and animals, indicating a conserved function during evolution.
Full conference title:
3rd EUROPEAN CONFERENCE ON FUNGAL GENETICS
- ECFG 3rd (1996)