The clinically important black yeast, Exophiala jeanselmei and its in vitrosusceptibility to antifungal agents

H. Badali, M. J. Najafzadeh, M. Vanesbroeck, E. Van den Enden, J. F. Meis, G. S. De Hoog


Introduction:Mycetoma is a localized chronic suppurative infection of subcutaneous tissue and contiguous bone that occurs following a traumatic inoculation of fungi or actinomycetes. Exophiala jeanselmei(order Chaetopthyriales) is a rarely-encounteredcause of subcutaneous lesions which can lead to eumycetoma. The species reportedly is common in the environment, but only clinical strains have been analyzed using molecular methods. Diagnosis ofE. jeanselmeiis currently achieved by sequencing the internal transcribed spacer (ITS) region of ribosomal DNA, which can distinguish species within this genus. The present studyaimed at re-identifying all strains maintained under the name “E. jeanselmei“ in the Centraalbureau voor Schimmelcultures (CBS; Utrecht, The Netherlands) and at establishing the clinical preference of the species. Given the high incidence of eumycetoma in areas where E.jeanselmeiis endemic, we also sought to evaluate the in vitrosusceptibility of E. jeanselmei towards 8 antifungal drugs.

abstract No: 

    • TIMM 4th (2012)