The Clinical Significance of Nephrotoxicity in Patients Treated with Amphotericin B for Suspected or Proven Aspergillosis

J WINGARD, P KUBILIS, L LEE, G YEE, M WIIITE, L WALSHE, R BOWDEN, E ANNAISSIE, J HIEMENZ, J LISTER.

Abstract: 

Patients receiving amphotericin B for suspected or proven aspergillosis in 5 transplant and cancer centers between 1990 and 1993 (N=239) were reviewed to determine nephrotoxicity, dialysis, and fatality rates. The mean and median duration of treatment were 20.4 and 15.0 days, respectively. Thee creatinine doubled in 53%, exceeded 2.5 mg/dl in 29%, dialysis was used in 14.5%, and death occurred in 60% of patients. Dialysis was necessary in 21 % of patients receiving both cyclosporine and other nephrotoxic agents and in 38% of patients in whom the creatinine exceeded 2.5. mg/dl. In a multivariate Cox proportional hazards analysis, allogeneic BMT patients (HR=6.34, p2.5 mg/dl (HR=42.02, p
1998

abstract No: 

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Full conference title: 

36th Annual Meeting of the Infectious Diseases Society of America
    • IDSA 36th