The biofilm phenotype is an increasingly important concept in mycological research. The escalating use of antibiotics combined with increased immuno-suppression amongst hospitalised patients has resulted in diverse fungal infections of biofilm origin from pathogenic yeasts and moulds. These include yeasts such as Candida albicans, which is the most notorious fungal biofilm former, and moulds such as Aspergillus fumigatus that have also shown to have the capacity to form biofilms. Collectively, these have distinct developmental phases that include adhesion, colonisation,maturation and dispersal. Clinically, these infections are difficult to manage with antifungal agents. This presentation will therefore provide an overview of important fungal biofilm infections, their clinical significance, and our improved understanding of fungal biofilm resistance mechanisms.
Full conference title:
Society for General Microbiology
- SGM 2012