Clinical Efficacy and Tolerability of Granulocyte Transfusions for the Treatment of Febrile Neutropenia in the Patients with Hematologic Malignancies.

Ki Hwan Kim1, Hyo-Jeong Lim*,2, Byung-Su Kim3, Sang-Min Lee*,2, Soo-Mee Bang4, Inho Kim*,1, Sung-Soo Yoon1, Kyou-Sup Han*,5, Seonyang Park1 and Byoung-Kook Kim*,1

Author address: 

1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National

Abstract: 

Poster Board III-83 Background: Bacterial or fungal infections in prolonged neutropenia are related to high mortality in patients with hematologic malignancies despite vigorous antibiotic and antifungal treatment. Granulocytes transfusions (GTs) have been used as an adjunctive to improve survival. However, the efficacy and safety of GTs are still controversial and reliable prognostic factors remain to be defined. This study aims to evaluate the clinical efficacy and tolerability of GTs and to assess the prognostic factors associated with survival outcome in the patients with neutropenia and severe infection. Methods: This study used prospectively collected comprehensive database, institutional leukapheresis registry. Adult patients (18 years) with hematologic malignancies who had received at least 3 times of GTs in each episode of febrile neutropenia (absolute neutrophil count
2009

abstract No: 

3146

Full conference title: 

51st American Society of Haematologists Annual Meeting
    • ASH 51st (2009)