Clinical characteristics of ocular candidiasis: when should fundoscopy be performed to rule out ocular candidiasis?

M. Nagao*, T. Saito, G. Hotta, S. Doi, M. Yamamoto, Y. Matsumura, A. Matsushima, Y. Ito, S. Takakura, S. Ichiyama

Author address: 

(Kyoto, JP)

Abstract: 

Objectives: Ocular candidiasis is a major complication of Candida bloodstream infection (BSI), but littile information is known about the clinical characteristics. This study was conducted to investigate the incidence, risk factors and the outcome of ocular candidiasis and the optimal timing of fundoscopy. Methods: We analyzed 216 cases with positive blood cultures of Candida species from January 2005 to June 2011 in two teaching hospitals to determine the incidence and the clinical characteristics of ocular candidiasis. Infectious diseases physicians in these hospitals performed proactive intervention in all of the Candida BSI cases and recommended fundoscopic examinations by ophthalmologists. Results: One-hundred sixty three of 216 Candida BSI cases had opthalmology consultations during the course of the antifungal therapy. Fifty-three (32.5%) cases had findings consistent with the diagnosis of ocular candidiasis, consisting of 44 cases with possible/probable chorioretinitis and nine cases with vitreitis. The groups with and without ocular involvement did not differ in age, sex, steroid use or diabetes mellitus, but more cases had digestive organ abnormalities or malignancies. Of these 53 cases, 42 (79.2%) were diagnosed within 7 days after a positive blood culture. The average time from a positive fungal culture to the diagnosis was 5.5 days. Twelve ocular candidiasis
2012

abstract No: 

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Full conference title: 

22nd European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 22nd (2012)