3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-; Citrinin (6CI); (-)-Citrinin; 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; NSC 186
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-
Chem abstract number:
Biochemistry of microorganisms. XLII. The metabolic products of Aspergillus terreus Thom. A new mold metabolic product-terrein. Raistrick, Harold; Smith, Geo. Biochemical Journal (1935), 29, 606-11. Production of citrinin by Aspergillus sp. of the Candidus group. Timonin, M. I.; Rouatt, J. W. Canadian Journal of Public Health (1944), 35, 80-8
Initially isolated as a broad-spectrum antibiotic but it is nephrotoxic and has an LD50 of 67 mg/kg body-weight when given subcutaneously or intraperitoneally in rats and 19 mg/kg body-weight when given intravenously to rabbits.
Aspergillus Species known to produce this metabolite:
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