Citrinin

Toxin: 

y

Trivial name: 

3H-​2-​Benzopyran-​7-​carboxylic acid, 4,​6-​dihydro-​8-​hydroxy-​3,​4,​5-​trimethyl-​6-​oxo-​, (3R-​trans)​-; Citrinin (6CI); (-​)​-​Citrinin; 4,​6-​Dihydro-​8-​hydroxy-​3,​4,​5-​trimethyl-​6-​oxo-​3H-​2-​benzopyran-​7-​carboxylic acid; NSC 186

Systematic name: 

3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-

Molecular formulae: 

C13H14O5

Molecular weight: 

250.25

Chem abstract number: 

518-75-2

Literature reference: 

Biochemistry of microorganisms. XLII. The metabolic products of Aspergillus terreus Thom. A new mold metabolic product-​terrein. Raistrick, Harold; Smith, Geo. Biochemical Journal (1935), 29, 606-11. Production of citrinin by Aspergillus sp. of the Candidus group. Timonin, M. I.; Rouatt, J. W. Canadian Journal of Public Health (1944), 35, 80-8

Chemical type: 

Benzopyran

Toxicity: 

Initially isolated as a broad-spectrum antibiotic but it is nephrotoxic and has an LD50 of 67 mg/kg body-weight when given subcutaneously or intraperitoneally in rats and 19 mg/kg body-weight when given intravenously to rabbits.

Structure image: 

Aspergillus Species known to produce this metabolite: 

3d image file .s3d (get free desktop viewer at http://www.acdlabs.com/resources/freeware/): 

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Date uploaded: 

2005-12-13 00:00:00