Circadian Rhythms in Development and Gene Expression in Aspergillus.

Andrew Greene, Nancy Keller, Hubertus Haas, and Deborah Bell-Pedersen.


The circadian clock controls daily cycles in biochemical, physiological, and behavioral processes and has been observed in organisms ranging from cyanobacteria to humans. Among the fungi, the circadian clock has been most extensively studied in the filamentous ascomyceteNeurospora crassa, and a detailed understanding of the mechanisms involved in generating circadian rhythmicity has emerged. While daily and circadian rhythms have been documented in other fungi, we know relatively little about the degree of conservation of clock components and mechanisms within the fungal kingdom. In order to begin addressing these questions, we have demonstrated circadian rhythms in development and gene expression in the ascomycetes Aspergillus flavus and Aspergillus nidulans, respectively. The A. flavus sclerotial rhythm has an unusually long free-running period of 33 hours and entrains to light:dark cycles in a unique manner. Additionally, the frequency gene, required for circadian rhythmicity in Neurospora under normal growth conditions, is not present in the sequenced genome of A. nidulans nor the closely related A. fumigatis species. These observations suggest that the circadian clock in Aspergillus is organized differently from that of Neurospora.

abstract No: 

Fungal Genet. Newsl. 50 (Supl):abstract

Full conference title: 

22nd Fungal Genetics Conference
    • Fungal Genetics Conference 22nd (2001)