Chemical composition and antifungal activities of the essential oil from Myrtus communis leaves

K. Zomorodian1,2, M.R.Moein3, Z. Goeini Lori3, M.J Rahimi2 , A. Bandegani1 , K. Pakshir1,2, S.Amini1

Author address: 

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Abstract: 

Background: The incidence of fungal infections has significantly increased over the past few decades, accompanying the growing number of high-risk patients, particularly those with impaired immunity. The majority of the clinically used antifungal drugs suffer from various drawbacks in terms of toxicity, drugdrug interactions, lack of fungicidal activity and the last but not the least the emergence of resistant strains. Hence, there is a great demand for novel antifungal agents, justifying the intense search for new drugs that are more effective and less toxic than those already in use. Aromatic plants have been used in folk medicine as antimicrobial agents since ancient times. The essential oils (EOs) from many plants are known to possess antibacterial and antifungal activity. The objective of this study is to determine the chemical composition and antfungal activities of essential oils from Myrtus communis L. (Myrtaceae) leaves. Materials and Methods: The chemical composition of essential oil from M. communis leaves was analysed by gas chromatography-mass spectrometry (GC-MS).The antifungal activities of the essential oil against seven American Type Culture Collection (ATCC) strains of Candida and Aspergillus species were determined. In addition, the antimicrobial activities of the essential oil against 39 clinical isolates of azole resistant and sensitive yeasts identified by PCR-RFLP were also examined. Results: GC-MS analysis revealed that the major constituents of the essential oil were -pinene (39.2%), 1, 8-cineole (22.0%) and linalool (18.4%). The essential oil exhibited antimicrobial activity against all tested clinical and standard fungi with MICs in the range of 0.03-16 μL/mL. All of the isolates showed MFC values of 8 μL/mL. Conclusion: The essential oil exhibited strong antifungal activities against all tested fungi, particularly against azole-resistance strains. The essential oil from M. communis leaves is a potential source of novel antifungal agents for the treatment of fungal infections. Keywords: Myrtus communis; Antifungal; Minimum Inhibitory Concentration; Candida; Aspergillus
2011

abstract No: 

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Full conference title: 

Iranian Congress on Medical Mycology
    • ICMM 2011