Objectives: To define demographic parameters, underlying diseases, aetiology, clinical features and survival rate in patients with central nervous system (CNS) aspergillosis in Saint Petersburg, Russia. Methods: Retrospective analysis. The diagnosis was established on the basis of EORTC/MSG 2008 criteria. Cases of proven or probable invasisve aspergillosis (IA) were included. Results: In 19982010 year. Two hundred and ninety-five cases of IA were registered in 19 hospitals in Saint Petersburg. CNS aspergillosis was revealed in 11 (3.7%) patients, three men and eight women, 467 years old (median 30.5), seven adults and four children. Primary host conditions were hematological disorders (55%) (including acute leukemia 36%), non-hematological malignancy (9%), viral meningitis (9%), infectious hepatitis (9%). Major risk factors were prolonged neutropenia (72%), lymphocytopenia (72%), cytostatic chemotherapy (64%), corticosteroid therapy (45%), stem-cell transplantation (9%), bacteremia (18%). Extra-CNS sites of infection were revealed in 82% of patients and included: lungs (55%), myocardium (9%), more than two organs (18%). The most common symptoms were: fever, headache, mental status alterations, drowsiness, dysarthria, hemiparesis ans seizures. Galactomannan test in serum and cerebrospinal fluid was positive in 72% of patients, positive histology in 36%, Aspergillus fumigatus was isolated from cerebral abscess in 9% of patients.
Full conference title:
22nd European Congress of Clinical Microbiology and Infectious Diseases
- ECCMID 22nd (2012)