Aspergillus fumigatus is an opportunistic pathogen and the most frequent cause of a severe invasive infection termed invasive aspergillosis. Similar to other fungi, this mold is surrounded by a robust cell wall that defines its shape and protects it from physical stress. We have characterized the cell wall integrity (CWI) pathway of A. fumigates. It comprises at least three major membrane anchored cell wall stress sensors with partially overlapping functions (Wsc1, Wsc3 and MidA), the guanine nucleotide exchange factor Rom2, a Rho GTPase, protein kinase C and a MAP kinase signaling module. We have shown that the principal CWI components are well conserved from yeasts to filamentous fungi. Though, the importance of the individual components for the fungal physiology, e.g., cell polarity and conidiation, may significantly differ. Our data stress the importance of the CWI pathway for the antifungal drug susceptibility and virulence of this pathogen.
Full conference title:
27th Fungal Genetics Conference
- FGC 27th (2013)