Cell wall degrading enzymes in Aspergillus flavus and fungal virulence

Jiujiang Yu 1, Natalie Fedorova 2, W illiam C. Nierman 2,3, Gary A. Payne 4, Joan W . Bennett5, Deepak Bhatnagar 1, and Thomas E. Cleveland 1

Author address: 

1 USDA/ARS, Southern Regional Research Center, New Orleans, LA, USA. 2J. Craig Venter Institute, Rockville, MD, USA. 3The George W ashington University School of M edicine, DC, USA. 4North Carolina State University, Raleigh, NC, USA . 5Rutgers Univ


The primary objective of our Aspergillus flavus genomics program is to understand the global regulation of toxin production by this fungus with a view to reduce or even eliminate aflatoxin contamination in food and feed, as well as control fungal infection in preharvest crops. An A. flavus EST and a whole genome sequencing project for this fungus have been completed. Genes that are potentially involved in aflatoxin formation and fungal infection have been identified. Data mining of the A. flavus genome has demonstrated that A. flavus possesses a whole array of genes encoding cell wall degrading enzymes. Gene expression studies in A. flavus indicate that these enzymes are highly expressed. These fungal enzymes could play an important role in the virulence of A. flavus and its ability to infect the crops. These enzymes probably contribute to the saprophytic property of A. flavus and can be explored for its potential benefit in biofuel production.

abstract No: 


Full conference title: 

6th International Aspergillus Meeting
    • Asperfest 6 (2009)