Medical records and laboratory data from 218 cases of canine coccidioidomycosis diagnosed at the University of California, Davis were reviewed. The diagnosis was based on clinical signs in conjunction with positive qualitative (including precipitin) and quantitative immunodiffusion serologic testing, histopathology, and mycology. Forty-three breeds were represented, as well as numerous mixed-breed dogs. Large and medium dogs predominated. Coccidioidomycosis occurred in young adult dogs most frequently. Males were affected more commonly than females. Clinical signs noted at presentation included fever, lethargy, par tial anorexia with associated weight loss, exercise intolerance, cough, and lameness. Primary pulmonic infection occurred most commonly. Evidence of extrapulmonary dissemination occurred most commonly to appendicular bone and overlying skin, but also included visceral (hepatic, splenic, renal), pericardial/myocardial, central nervous system, ocular, and prostatic involvement. Extrapulmonary dissemination was associated with a poorer prognosis and increased incidence of euthanasia or death. Primary coccidioidal osteomyelitis occurred infrequently. Therapy included amphotericin B, ketoconazole, itraconazole, and an experimental azole.
Full conference title:
Coccidioidomycosis - Centennial Conference